One of the less well-known skin disorders of the lower genital tract is called plasma cell vulvitis or plasma cell mucositis. It is often mis-diagnosed as “vulvodynia”. Like all autoimmune skin conditions, it is chronic but may have flares or may be intermittently symptomatic. The skin of the vaginal opening is typically involved, often including the urethra. Patients frequently complain of a burning, raw, painful sensation that is made worse with urination or intercourse. Due to the frequent involvement of the urethra, patients often experience symptoms of a “chronic urinary tract infection”. This condition has not been associated with an increased risk of cancer. Treatment for plasma cell vulvitis usually involves maintenance therapy including topical medicines to provide relief of the symptoms.